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Hence, one potential explanation for the increased efficacy of tirzepatide on glycemic control relative to the monoagonist GLP-1RA is that targeting both incretin receptors maintains some insulinotropic activity even in subjects who are relatively insensitive to GLP-1
Consequently, compensatory activated collateral blood vessels and reorganized blood flow following BPC 157 treatment in rats with the occluded major peripheral vessel(s) or central vessels reduced superior sagittal sinus, portal and caval hypertension, aortal hypotension, progressive venous and arterial thrombosis peripherally and centrally, and ECG disturbances
But, they might be given more often, like weekly, based on how the patient responds
This idea is indirectly supported by a study in fibromyalgia patients where supplementation with another key mitochondrial agent, CoQ 10 , increased low peripheral serotonin values (7)
