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Different GLP-1 RA have different dosing requirements, such as: Before Meals: Oral semaglutide (Brand name: Rybelsus) taken 30 to 60 minutes before meals Once-daily injections: Lixisenatide (Brand name: Adlyxin) Liraglutide (Brand names: Victoza, Saxneda) Once-weekly injections: Dulaglutide (Brand name: Trulicity) Semaglutide (Brand name: Ozempic) Extended-release exenatide (Brand names: Bydureon, Bydureon BCise) Naturally produced GLP-1 RAs versus GLP-1 Therapies The natural hormone, called endogenous GLP-1 RA produced by the body is released in response to glucose

The modification was developed to help enhance the half-life of the protein and allow it to obstruct the normal FOXO4 function