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Ensure you're eating enough protein (at least 0.8 grams per pound of target body weight daily) to preserve muscle mass during weight loss
Negative impacts on energy or mood are uncommon
74 For instance, in the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial, weekly semaglutide administration resulted in a mean body weight reduction of 14.9% from baseline among overweight or obese non-diabetic individuals, 76 a magnitude of weight loss previously observed only following bariatric surgery
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