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In practice this means three differences
Severe or refractory RLS symptoms may warrant referral to a sleep medicine specialist or neurologist
The injections are relatively painless, using very thin needles, but the process requires some instruction and comfort with self-injection
Abnormalities in the spiking of GABAergic interneurons within the prefrontal cortex has been implicated in the pathophysiology of multiple psychiatric disorders including schizophrenia
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