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Nauck MA, Heimesaat MM, Orskov C et al (1993) Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
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However, other studies show no effect, so more research is needed
This was achieved through careful selection of amino acid residues, particularly in the N-terminal region centered around the unmodified His1, and through optimization of the mid-chain and C-terminal regions to simultaneously support binding at all three receptors
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