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These results are consistent with the major features of hind-limb suspension-related phenotypes of skeletal muscles as an index of anti-gravity muscle atrophy 66 , thus assuring that the experimental design including the mouse age and muscle-disuse period (in vivo assay time-point) were appropriate to the conclusion that 3-days LASSS oral-administration prevents tyrosine-residue nitration of extracellular HGF (Y198) during 5-days muscle disuse

10.1093/toxsci/kfx230 111 WongY

Research has explored its potential interactions with cortisol and luteinizing hormone (LH) secretion, as well as its activity on opioid receptor pathways and antioxidant mechanisms at the cellular level, making it a versatile subject across neuroscience, endocrinology, and oxidative stress research models

Additionally, since the interactions between viscosity-reducing excipients and proteins may be transient and low-affinity (dissociation constants exceeding 1 mM 171 ), measurement of the protein-excipient interactions may be quite difficult via common biophysical techniques excepting some structural approaches such as NMR