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Notable examples include CALAA-01 (a cyclodextrin-based siRNA delivery system) and BIND-014 (a targeted polymeric NP for docetaxel delivery), both of which showed strong preclinical efficacy but were discontinued due to limited therapeutic benefit and safety/scale-up challenges in human trials [209,210]

4 The mechanisms and pathways of GLP-1 regulating blood glucose 4.1 Promotion of insulin synthesis Transcription factors regulate gene expression by binding to specific enhancer sequences