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In terms of glycemic control, these agents affect glucose metabolism through distinct pathways: GLP-1RAs enhance glycemic control by stimulating glucose-dependent insulin secretion, while SGLT2is lower blood glucose levels by inhibiting glucose reabsorption in the proximal renal tubules, leading to increased urinary glucose excretion
10.1016/j.tiv.2013.11.015 11
Hyperglucagonemia Increases Resting Metabolic Rate in Man During Insulin Deficiency
L-carnitine also enhances energy metabolism by increasing carbohydrate utilization and reducing protein breakdown [21]
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