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Abbreviations FA: fatty acid CPTI: carnitine palmitoyltransferase I FAO: fatty acid oxidation FAS: fatty acid synthesis CACT: carnitine acylcarnitine translocase mTORC1: mTOR complex 1 LOA: loss of attachment ROS: reactive oxygen species FDG: 2-deoxy-2-fluoro-D-glucose ACC1: acetyl-CoA carboxylase 1 ACC2: acetyl-CoA carboxylase 2 CoA: coenzyme A ARMS: alveolar rhabdomyosarcoma RXRs: retinoid X receptors PRL: prolactin HDAC1: histone deacetylase 1 ECs: endothelial cells References Hanahan D, Weinberg RA
Molestias digestivas (las ms comunes) Nuseas: entre 20% y 44% de los pacientes (ms comn al inicio y con dosis altas) Vmitos: entre 10% y 24% Diarrea: entre 12% y 30% Estreimiento: entre 6% y 24% , segn la molcula y la duracin En general, 4 a 7 de cada 10 pacientes (40-70%) presentan algn sntoma digestivo durante el tratamiento, sobre todo en las primeras semanas, con tendencia a mejorar con el tiempo (1,8-11)
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Mice were divided into weight-matched groups, ( n = 8
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