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Abstract 54-OR

The Molecular Targets Driving the Revolution Modern incretin-based therapies harness three key hormone receptors that work together to regulate glucose metabolism, appetite, and energy balance: GLP-1R (Glucagon-Like Peptide-1 Receptor) Activated by drugs such as Semaglutide , this receptor stimulates insulin secretion, slows gastric emptying, and promotes satiety, helping reduce food intake and improve blood glucose control

Yet in natural settings, outside the lab, many patients suffer from a mix of the two diseases, with similar mitochondrial dysfunction affecting multiple cell types

pgap1 D:: KANMX-pGSH1/pgap1 D:: KANMX-pGSH1) selected on YNB agar lacking histidine and supplemented with kanamycin