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The most frequently reported adverse effects were gastrointestinal in nature, generally mild to moderate in severity and transient, typically occurring during the dose-escalation period

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Methods We used a combination of glucagon secretion measurements in mouse and human islets (including islets from donors with type 2 diabetes), total internal reflection fluorescence microscopy imaging of secretory granule dynamics, recordings of cytoplasmic Ca 2+ and measurements of protein kinase A activity, immunocytochemistry, in vivo physiology and GTP-binding protein dissociation studies to explore how GLP-1 exerts its inhibitory effect on glucagon secretion and the role of the metabolite GLP-1(936)

First, these are averages individual response varies widely, and some patients respond better to semaglutide for reasons that are not yet fully understood