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Large-scale randomised controlled trials, including the STEP 1 trial (Wilding et al., NEJM 2021) for semaglutide 2.4 mg, have demonstrated clinically meaningful and sustained weight loss in adults with obesity or overweight with weight-related comorbidities

A few specific studies have clearly demonstrated: Choline supplementation normalized cholesterol metabolism, which was sufficient to prevent nonalcoholic steatohepatitis development and improve liver function

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