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Again, there were no new diagnoses within 1 year or during the L-carnitine supplementation, and medications were unchanged for at least 4 months before and during the study
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[75] An observational study on patients with obesity and type 2 diabetes and heart failure with preserved ejection fraction reported that tirzepatide had a lower risk of hospitalization for heart failure and all-cause death combined than sitagliptin
However, because it carries a risk of rare but potentially life-threatening complications, is subject to sample variability (ie, samples may come from liver regions that are more or less affected), and is expensive, it is generally reserved for patients for whom medication or surgery is being considered and those whose condition is uncertain
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