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Beyond classical checkpoint pathways, osteosarcoma cells express dont eat me signals that protect them from phagocytosis
During the titration phase (weeks 1-20), participants often see gradual weight loss of 1-2 pounds per week as doses are increased, reduced appetite and food cravings within the first 2-4 weeks, improved satiety and easier adherence to reduced-calorie diets, and early body gains (better glucose control, reduced blood pressure)
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