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In this paradigm, aquaporin 8 silencing, which is specifically expressed in IMM, enhances mitochondrial ROS generation and results in mitochondrial depolarization and cell death ( 2 O 2 at higher rates than complex I from mitochondria (Quinlan et al., 2014)

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Additionally, increased fasting blood glucose and insulin resistance were also observed in Gpx4 / AT mice, and spontaneously produced impaired insulin signaling in the liver, resulting in systemic inflammation and disorders of glucose metabolism (43)