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19(8):969-988 Peptide Sequence: Gly-His-Lys(Cu2+) GHK-Cu Human Trials A 2% GHK gel showed promising results in treatment of 120 diabetic patients, increasing the percentage of ulcer closure from 60.8% to 98.5%, and decreasing the percentage of infection from 34% to 7%

The American Diabetes Association/European Association for the Study of Diabetes consensus report recommends the use of GLP-1 RAs throughout the treatment pathway in patients with T2DM not controlled by metformin monotherapy as well as comprehensive lifestyle modifications, especially if there is concern about weight gain or hypoglycemia, or as an initial agent if metformin is contraindicated [13]

Additional concerns, as reported by the FDA, include compounding multiple GLP1 receptor agonists together leading to serious side effects

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