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Much of the progress with metabolite ratios to date has focused on alterations within a given metabolic pathway, while a relatively limited amount of epidemiological research has explored the relationship between metabolites across pathways

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Additionally, we found that reduced E1A-binding protein p300 (p300)-mediated crotonylation is a major cause of the altered STXBP1 crotonylation in the hippocampus of epileptic mice