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alternative routes have unknown safety implications Efficacy : The dose-response relationship established in trials assumes subcutaneous delivery Tolerability : Gastrointestinal adverse effects (nausea, vomiting, diarrhea) are dose-dependent and may be affected by altered absorption Patients with lower body mass index or those injecting in areas with less subcutaneous fat may be at higher risk of inadvertent intramuscular injection if proper technique is not followed

Oral tirzepatide options , tirzepatide drops , and tablet formulations provide the same active medication without the subcutaneous delivery that causes local reactions

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[Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]