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The conventional antidote for acetaminophen toxicity, N-acetyl cysteine (NAC), begins to lose efficacy if administered more than 8-10 hours following overdose (Smilkstein 1988
Both studies were placebo-controlled and randomized, but in one trial, participants were also taking positive airway pressure therapy, a standard treatment for sleep apnea
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Alcohol can slow healing and increase inflammation, so avoiding alcohol or drinking minimally is advised during treatment
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