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Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue

Healthy fats deserve special attention because they increase satiety signals and help absorb fat-soluble vitamins (A, D, E, K)

Bar plots in Venn diagrams show the mean log2 fold change of the regenerated versus resected normalized counts for all metabolites in the intersect or individual subsets [either OE or GFP], error bars represent S.E.M

Prescriptions are issued only when clinically appropriate