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The combination results in three convergent signals: reduced caloric intake (GLP-1/GIP appetite suppression), improved insulin sensitivity (GIP/GLP-1 pancreatic effects), and elevated calorie burn (glucagon thermogenesis)
As an extending point, there appears to be fistula healing (i.e., simultaneous healing of the skin and other tissues wounds) (Klicek et al., 2008
doi: 10.3390/ijms23126806
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