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proposed that the research on the treatment for immune-mediated diseases, such as rheumatoid arthritis, should attempt to achieve a more comprehensive understanding of various disease-related biomarkers, conducting large-scale high-throughput data analysis, and identifying and quantifying the disease metabolites (37)

The absence of glucose effects means dosing does not need to be coordinated with meals or adjusted for diabetic status, and there are no concerns about timing relative to insulin sensitivity

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