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The major risks are from the acute effects of exercise on glucose concentrations, which depend on several factors, including: the baseline fitness of the individual and type, intensity and the duration of activity
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In the STEP 1 phase-3 trial, once-weekly semaglutide 2.4 mg achieved about ~15% of total body weight in mean weight loss over 68 weeks, substantially more than placebo, with gastrointestinal symptoms the most common adverse events [6] [7]
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