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Additionally, TPL-induced DNA damage (e.g., topoisomerase II inhibition causing double-strand breaks) and G1 phase cell cycle arrest ( via p21 upregulation and CDK suppression) exacerbate genomic instability and proliferation inhibition (Zhang H
Specifically, our published data confirms that exendin-4, significantly improves ALD pathology by reducing hepatic steatosis, inflammation, and oxidative stress in experimental rats (Mahalingam et al., 2023)
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