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They also play a role in maintaining islet cell mass and function, which is crucial in diabetes management.7 GLP-1 agonists influence multiple organs, notably the brain, pancreas, liver, kidneys, heart, and blood vessels, enhancing neuroprotective actions and mitigating systemic inflammation which may benefit recovery post-spinal surgery.2 Clinical Implications and Pre-Operative Considerations Specifically, GLP-1 agonists protect and proliferate pancreatic islet B cells, promote nerve growth, reduce neuroinflammation, improve cardiac function, decrease appetite, slow gastric emptying, modulate lipid metabolism, and reduce fat deposition.6 Their impact on slowing gastric emptying is particularly relevant when considering the timing of medication cessation prior to surgery to minimize aspiration risk
It has been shown that KD may have anti-tumor potential for several cancer types, including colorectal, brain, breast, and pancreatic cancer (81, 82)
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