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Phthalimide conjugation as a strategy for in vivo target protein degradation

These findings indicated that TGF-1 + IL-1 was sufficient to induce fibroblast activation by activating NLRP3 inflammasome, but insufficient to cause NLRP3/caspase-1/GSDMD-mediated fibroblast pyroptosis, while the underlying mechanism remains to be further explored