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Glutathione is one of the key tools the liver uses to bind, neutralize, and help remove harmful compounds from the body
The green curve shows the time course of the percentage of functional hepatocytes if the NAC rescue is performed at 2 hours after the dose was ingested
Similar findings were recapitulated for the second most abundant caffeine metabolite (12% of total), theobromine, also mapping on the CYP2A6 region ( Online Supplementary Figure S3A, B)
Berberine can lower blood glucose and may potentiate the effects of diabetes medications, including metformin, sulfonylureas, and insulin, potentially causing hypoglycaemia
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