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When animals were treated with the mitochondria-targeted MnSOD mimetic Mito-TEMPO, the prevention of peroxynitrite formation due to superoxide dismutation eliminated necrotic cell death 6 h after APAP administration with no evidence of apoptosis [29, 58]
Ministry of Science and Technology of China Major Project XDB08020303 (H.E.X.)
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Although many preclinical studies suggest that GLP-1R agonism can act directly on neurons to prevent cell death, this neuroprotective property may be secondary to reduced glucotoxicity and inflammation in the brain that can result from weight loss and improvements in glycemic control (Berkseth et al., 2014)
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