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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

Men with obesity or metabolic syndrome often exhibit functional hypogonadism (low testosterone levels due to excess adiposity) and impaired sperm parameters, as well as higher rates of erectile dysfunctionfrontiersin.orgmdpi.com

Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]

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