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Additional experiments showed that increasing GSH levels using glutathione diethyl ester worsened diabetes, whereas blocking GSH synthesis with L-buthionine sulfoximine improved glucose tolerance, further highlighting the importance of GSH metabolism in disease progression

Yasmine Abdel US 1 review Apr 4, 2025 Individual results may vary

Later on, additional roles for the antioxidant function of GSH have emerged that are strictly related to signal transduction: (i) the interaction of the tripeptide with NO or with RNS (see next section)

Debunking the myth: Broader application: While GLP-1 agonists were originally developed for the treatment of type 2 diabetes, their benefits extend beyond blood sugar control