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Secondary outcomes included progression to permanent AF defined as a clinical diagnosis coded by the treating physician ( International Classification of Diseases code I48.2) where both the patient and physician have agreed to manage the condition with rate control rather than attempting cardioversion, all-cause mortality, hospitalization for heart failure, cardiovascular-related hospitalizations, repeat ablation procedures, atrioventricular node ablation, and a composite of cardioversion or amiodarone initiation

However, the production of IL-1 during the GA process is puzzling, with studies reporting that MSU crystals alone do not participate in the transcription of IL-1 but only in the regulation of the conversion of inactive IL-1 to an activated state (40)

In this scenario, semaglutide is the ibuprofen