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Butyrate promotes production of extra-thymic T reg cells in an intronic enhancer CNS1-dependent manner if administered systemically, but increases only intracolonic T reg cells production if administered locally via an enema (71)

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The electronic search encompassed a number of databases, including PubMed, MEDLINE, Embase, Web of Science, and Reprotox, covering the period from database inception through January 2026

But the adaptation goes further: the body also down-regulates calorie burning beyond what the change in size alone would predict