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The occurrence of ferroptosis in mature erythrocytes has not been confirmed and it seems quite challenging, since ferroptosis studies suffer from the lack of well-established markers and evaluation of this cell death requires a complex approach with identification of typical cellular and subcellular morphological alterations, genetic hallmarks, biochemical changes, expression of certain ferroptosis-related proteins, etc
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Droujinine and Perrimon, 2016
This aberrant methylation pattern has also been observed in E-cadherin and non-transforming Wnt ligands (Wnt5a, 7a, and 9a), leading to constitutive activation of the Wnt/ -catenin pathway and uncontrolled cellular proliferation (Ying and Tao, 2009)
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