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10.1016/j.pbb.2015.01.015 90 GuoC.ZhangG.WuC.LeiY.WangY.YangJ

When semaglutide binds to GLP-1 receptors on pancreatic beta cells, it stimulates glucose-dependent insulin secretion

It raises insulin, lowers glucagon, and slows gastric emptying

Medication review: Some patients find better results with tirzepatide (Mounjaro / Zepbound), which stimulates both GLP-1 and GIP receptors, offering a stronger metabolic effect than Semaglutide alone