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These nuclear receptors are composed of three isoforms: PPAR stimulates mitochondrial fat oxidation in hepatocytes, PPAR attenuates inflammation in Kupffer cells and PPAR reduces fibrosis [107]
As such, these dual agonists are often sold as sequels or improvements to mono agonists
Gemigliptin and evogliptin were soon approved in Korea, and gosogliptin was approved in Russia
In addition, it does not increase ghrelin, so you wont end up with an increase in appetite
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