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SCFAs play an important regulatory role on various immune cells, particularly those central to maintaining immune homeostasis and anti-inflammatory responses, by inhibiting HDAC

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255 Similarly, Sandalwood seed oil has been shown to improve insulin resistance in rats induced by a high fat/high sugar diet, with mechanisms related to changes in gut microbiota composition and the production of microbial metabolites (including TMAO)

The table below highlights how these treatments compare: This evidence highlights the advantages of combination therapy, particularly for PCOS patients with a BMI 25 kg/m and for individuals with type 2 diabetes who struggle to meet glycemic targets on metformin alone