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For the survival cohort study, Rosa26-creERT2 ;Gpx4 f/f mice were intraperitoneally treated with tamoxifen (Sigma-Aldrich, T2859, 2 mg per day dissolved in Myglyol 812) on days 0 and 1 for deletion of Gpx4 in the whole body except in the brain 2
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It fundamentally alters cellular behavior, gene expression, and tissue remodeling processes
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