Elevated homocysteine levels in the blood (i.e., hyperhomocysteinemia) may be a risk factor for cardiovascular disease and could also be linked to dementia and Alzheimers disease (20, 21)
Mtb whiB3 has significantly increased levels of EGT when catabolizing a diverse set of fatty acids, such as stearate, myristate, and palmitate, when compared with glucose (52)
GSH brain concentrations are not commonly measured using 1 H-MRS, because relative to other 1 H-MRS-detectable neurochemicals (e.g., creatine (Cr), choline, N -acetylasparate), GSH concentrations are substantially lower
Finally, these observations provide a unique example of an intervention which appears to favor female healthspan and lifespan, thereby reinforcing the need for considering sex differences in devising therapeutic strategies to treat aging and its diseases