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Lactate promotes lactic acidification of histone H4 lysine 12 (H4K12la) by downregulating histone lysine delactase, inducing the enrichment of H4K12la in the SASP promoter region and SASP transcriptional activation to promote VSMC senescence
Semaglutide 2.4 mg (Wegovy, FDA-approved for weight management) reports diarrhea in approximately 30% of patients in clinical trials according to the FDA prescribing information
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