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Inflammatory cytokines in ovarian cancer cells, including tumor necrosis factor- (TNF-) and interleukin-1 (IL-1), promote malignant progressionsuch as tumor cell migration and invasionby upregulating the expression of vascular cell adhesion molecule-1 (VCAM-1) and ICAM-1 [79,80,81,82]

Most patients with depression show mood disturbances, as well as general cognitive impairment, which may explain the two-fold greater risk of dementia development seen in such patients (Kohler et al., 2010

The most impressive structural feature of peptide 20 is the lipidated K10 P by a 16-carbon palmitic acid through a -carboxylate spacer, which perfectly inserted into the TM1-TM2 crevice and made extensive contacts with both receptors and lipid membrane to stabilize the binding poses (Fig

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