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Diabetes 63 , 471482 (2014)

Zepbound (tirzepatide) is an FDA-approved prescription medication indicated for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbid condition, such as hypertension, type 2 diabetes, or dyslipidemia

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Gene variants and polymorphisms The study of pharmacogenomics in recent decades has proved that genetic polymorphism of drug-metabolizing enzymes is an important mediating factor in determining individual drug responses