GLP-1R is expressed in the heart, kidneys, liver, and brain, which is why the clinical literature documents cardiovascular, renal, and neuroprotective effects well beyond glycemic control
Tirzepatide is known to mimic hormones that signal satiety to the brain and may start to reduce appetite sometimes soon after treatment begins, as part of its mechanism of action
The drugs also warn about side effects like pancreatitis, diabetic retinopathy, low blood sugar, kidney problems, allergic reactions and sudden gallbladder disease
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