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One of the most commonly-reported side effects of SSRIs is weight gain, and it's one of the most frequently-cited reasons for discontinuing taking SSRIs
The SUSTAIN-6 trial demonstrated a 26% reduction in heart attack, stroke and heart related deaths in adults with type 2 diabetes and coronary artery disease or multiple heart risk factors
But tirzepatide is a brand-name biologic with no generic equivalent, and that changes the math significantly
The terminal half-life of MEDI4166 in cynomolgus monkeys based on Fc and GLP-1R activity in the 100 mg/kg (sc) group were determined to 147 and 116 h respectively (Supplementary Table 4)
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