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For example, a head-to-head trial (SURMOUNT-5) reported 20.2% weight loss with tirzepatide vs 13.7% with semaglutide 2.4 mg over ~72 week

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L-carnitine supplementation significantly improved LVEF (MD = 1.64, 95% CI 0.103.17, p = 0.04), with low heterogeneity ( I 2 = 37%)