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A reduction in IL-2 cytokine expression can affect not only the proliferation of pro-inflammatory Th1/Th17 cell subsets promoting ALS progression, but can also increase Treg/Th2 subsets that provide anti-inflammatory stimuli resulting in protection during an inflammatory event

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63 , was PPG expression actually quantified

The ability to predict compound concentrations and exposure durations that could cause a significant compromise in cellular antioxidant defence as a function of a physicochemical property, especially with respect to an understated mechanism such as redox cycling, could prove to be extremely useful when investigating toxicity with the reduction of animal models in mind