Sulfation (Safe Pathway) DECREASES 33% The Brookhuis 2021 data showed: The estimated molar dose fraction of acetaminophen-sulphate decreased with the duration of pregnancy (24.2 (22.326.2%), 21.5 (19.923.1%) and 20.7 (19.122.4%) in the first, second and third trimester, respectively) compared with non-pregnant women (31.1 (29.033.3%)).[] **This is a 33% DECREASE in the safe sulfation pathway by third trimester** (20.7% vs 31.1%)
Yes, many people prefer taking these in the morning before food
10.1371/journal.pone.0114726 150 KimH.ParkS.-Y.LeeG
The NHS symptoms list groups them into general anaemia symptoms (tiredness, breathlessness, headaches, loss of appetite, weight loss) and neurological signs (peripheral neuropathy, balance problems, depression, memory and concentration changes, sometimes mood changes or psychosis in advanced cases)