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PDI is S-nitrosylated in lumbar spinal cords of sporadic ALS patients (Walker et al., 2010), which abrogates PDI-mediated attenuation of neuronal cell death triggered by ER stress or misfolded proteins (Uehara et al., 2006)
It has been known since the writing by Lavoisier in the late 1700s that oxygen can cause damage to the lipids of animal cells [37], as recounted in [38]
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