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Start your intake How GLP-1 Medications Are Processed by the Liver and Kidneys Both semaglutide and tirzepatide are peptide medications that undergo hepatic metabolismmeaning the liver breaks them down into inactive metabolites that the kidneys then filter and excrete

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The initial dosing regimen of semaglutide subcutaneous injection is 0.25 mg weekly, with the dose increased up to 2 mg for Ozempic and 2.4 mg for Wegovy , respectively, usually after one month at the previous dose