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Official AASLD Guidance on the management of malnutrition, frailty and sarcopenia in patients with cirrhosis

Its weight-related effects are more modest and occur through: Reducing hepatic glucose production, which lowers circulating insulin levels Improving insulin sensitivity in peripheral tissues Potentially affecting appetite regulation Modest reduction in intestinal glucose absorption Metformin typically produces weight loss of 23 kg on average, or may prevent the weight gain often associated with other diabetes medications

(PubMed) Rhodes A, Evans LE, Alhazzani W, et al

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