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Contrave came first in 2014
GLP-1 receptor agonists-SGLT-2 inhibitors combination therapy and cardiovascular events after acute myocardial infarction: an observational study in patients with type 2 diabetes
On average, the participants experienced 10% weight loss and saw their testosterone levels rise from 53% to 77% over 18 months
That means the active ingredient is designed to mimic a natural gut hormone called GLP-1, which your body releases after eating to help manage blood sugar and signal fullness
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